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![]() | Julie A. Leary Professor Email: jaleary@ucdavis.edu Phone:(530) 754-4987 1977 Sigma Xi undergraduate award 1984 Eastern Analytical Grad Student Award 1985 PhD Massachusetts Institute of Technology - Chemistry 2000 Biemann Award in Mass Spectrometry Group Page |
| Principal Research Interests | |
My group is interested in probing structures of macromolecular complexes using mass spectrometry. This includes protein: carbohydrate interactions as well as protein:protein interactions occurring during viral infection of host cells. | |
| Representative Publications Julie A. Leary 1. Mougous, J.D., Petzold, C.J., Sanartne, R. H., Lee, D.H., Akey, D.L., Lin, F.L., Munchell, S.E., Pratt, M.R., Riley, L.W., Leary, J.A., Berger, J.M., Bertozzi, C.R. Identification, Function and Structure of the Mycobacterial Sulfotransferase that Initiates Sulfolipid-1 Biosynthesis, Nature Struc. Molec. Bio.. 2004, 11, 721. 2. Pi, N., Meyers, C.L.F., Pacholec, M., Walsh, C.T., Leary, J.A.; Mass Spectrometric Characterization of a Three Enzyme Tandem Reaction for Assembly and Modification of the Novobiocin Skeleton, Proc. Natl. Acad. Sci. , 2004, 101, 10036. 3. Leary, J. A., Pi, N., Yu, Y.; Mass Spectrometry: A Chemical Biology Tool for Probing Enzymatic Systems, Advances in Mass Spectrometry, 2004, vol. 16, pp.325. 4. Petzold, C.J., Leavell, M.D., Durkin, K.A., Leary, J.A.; Investigation of the Fundamental Reactivity of Trimethylsilyl Chloride with Phosphorylated, Sulfated, and Carboxylated Anions: FT-ICRMS and DFT Calculations, submitted to Angew. Chemie. 5. Yu, Y., Kirkup, C., Pi, N., Leary, J.A. Characterization of Noncovalent Protein-ligand Complexes and Associated Enzyme Intermediates of GlcNAc-6-o-Sulfotransferase by Electrospray Ionization FT-ICR Mass Spectrometry, in press, J. Amer. Soc. Mass Spectrom. 6. Saad, O, and Leary, J.A. "Delineating Mechanisms of Dissociation for Isomeric Heparin Disaccharides Using Isotope Labeling and Ion Trap Tandem Mass Spectrometry, in press, J. Amer. Soc. Mass Spectrom. 7. Gao, H., Leary, J.A.; Kinetic Measurements of Phosphoglucomutase by Direct Analysis of Glucose-1-phosphate and Glucose-6-phosphate Using Ion/Molecule Reactions and FT-ICR Mass Spectrometry , Anal. Biochemistry, 2004, 329, 269. 8. Pi, N., Leary, J.A.; Determination of Enzyme Substrate Specificity using a Multiplex ESI-MS Assay, J. Amer. Soc. Mass Spectrom., 2004, 15, 233. 9. Leavell, M.D., Petzold, C.J., Leary, J.A., Screening and Identification of Acidic Carbohydrates in Bovine Colostrum by using Ion/Molecule Reactions and FTICR:Specificity toward Phorphorylated Complexes Anal. Chem. 2004, 76, 203. 10. Pi, N., Yu, Y., Mougous, J.D., Leary, J.A., Observation of a Hybrid Random Ping-Pong Mechanism of Catalysis for NodST: A Mass Spectrometry Approach, Prot. Science, 2004, 13, 903. 11. Gao, H., Petzold, C. J., Leavell, M.D., Leary, J.A. Investigation of Ion-Molecule Reactions as a Quantification Method for Phosphorylated Diastereomers: An FT-ICR Approach J. Amer. Soc. Mass Spectrom, 2003, 14, 916. 12. Saad, O., and Leary, J.A. Compositional Analysis and Quantification of Heparin and Heparan Sulfate by Electrospray Ionization Mass Spectrometry Anal. Chem. , 2003, 75, 2985. 13. | |